【製品名（商品名）】
媛美月
【種類】
Citrus unshiu
【卸地】
愛媛県八幡浜市江戸岡（西宇和農協（八協柑橘共同選果部会）
【名前の由来】
The highest quality mandarin oranges co-selected by JA Nishiuwa Hachikyo, which selects only fruits with a well-balanced sugar content and acidity from the fruits that have been engaged in high-quality production, and the day when it was developed with the production area is full moon. Was it beautiful?
【主な特徴】
Social Welfare Corporation Yawatahama City Council of Social Welfare (matsukaya): 2021 Abuse Prevention Seminar
“Corona stigma and human rights-the dignity of the individual we face” In Japan, we are guaranteed the dignity of the individual to live happily in our own way through free social activities, and we are positioned as a right that will not be violated. On the other hand, the new coronavirus infection, which continues to spread worldwide, still restricts all our social activities even after about two years, and various medical institutions and welfare facilities are used to prevent infection. At the same time as taking various measures, restrictions on going out and visits, reduction of service provision, etc. are unavoidable. In addition, this invisible infectious disease threatens the dignity of the individual, as it induces prejudice and discrimination against health care workers and infected people. We do not always think about how to protect the right of everyone to live in their own way, freely and happily, and how to harmonize with the restrictions imposed by infectious disease control. must not. The seminar is held as an opportunity to reconsider the dignity of the individuals we face in the spread of infectious diseases and to practice better support. Date and time: Tuesday, March 22, 2022 from 18:30 to 20:30. Coronavirus infections can be transmitted without anyone noticing, even if they are careful, and we can be infected at any time by ourselves or our family. Under such circumstances, cases of discrimination and accusation based on misunderstandings and prejudices against infected people have been reported in various situations of daily life such as at work, school, and SNS. We need to think about how we feel when we and our families are subject to such discrimination and accusation. The Universal Declaration of Human Rights was adopted at the Third General Assembly of the United Nations on December 10, 1948. The Universal Declaration of Human Rights stipulates the principle of respect for basic human rights. In Japan, one week (between December 4th and December 10th) with December 10th as the final day is designated as Human Rights Week. It has been established and is developing human rights awareness activities nationwide. Article 1 states, “All human beings are born free and equal in dignity and rights. Human beings are endowed with reason and conscience and act in the spirit of their compatriots and brothers. Must be done.” Isn’t it possible to return to good old Japan by deepening our understanding of the idea of respect for human rights, caring for others, and building a society where everyone respects each other’s human rights? His birthday is today. In Japan, Eiichi SHIBUSAWA will be the face of the new 10,000 yen note from 2024. The highest denomination banknote is literally the face of the country, and it is probably the world’s common sense to choose from the people and landscapes that symbolize the country. His wise saying, which was a minority ally, still remains and is inherited. It is, “People do not try their best if they do not benefit themselves.” Not surprisingly, we will not have the leeway to make people happy unless we are happy first. It is wrong because it will definitely go bankrupt in the long run, such as working for the benefit of others even if you disregard your own interests. However, he correctly understands the simple needs of human beings, designs capitalism based on realism, and spreads it in Japan. It is strange that we, the country where only the managers are enriched. All of our employees and business partners are breaking the essence of selfish capitalism at the time, even if the economy, which is not equally prosperous, never goes well. In Japan, the value of banknotes has increased dozens of times compared to those days, but can we all manage to change the shape of the deflationary spiral from the Heisei era to the Reiwa period? Those who cannot afford it have the right to face and know now. Japan, which has the slowest economic recovery as a developed country in the world, yes, I cannot help feeling close to it. Yawatahama City, Ehime Prefecture is located at the base of the Sadamisaki Peninsula at the western end of Ehime Prefecture, facing Kyushu across the Bungo Channel (Uwa Sea), and is a port town boasting one of the highest landings in Shikoku. Warm climate and terraced field (A field created in a staircase on a slope such as a hillside. It seems to be found in a densely populated area on a flat land. In the case of paddy fields, it is called a terraced rice field.) Setouchi Citrus cultivation that makes the best use of the coastal topography of the sea is flourishing, including branded oranges known throughout the country such as “Hinomaru”, “Maana”, “Kawakami”, “Mitsuru”, and in recent years “Beni Madonna” “Setoka”, “Kanpei”, etc. It is known as the number one citrus kingdom in Japan for citrus production. No, it is a world-famous production area. The variety of citrus cultivation that is one of the characteristics of “Hachikyo” is various, such as iyokan (species of citrus fruit, Citrus iyo), Citrus reticulata（Ponkan）, dekopon (Citrus reticulata Siranui), Kiyomi, etc. In addition, he is also focusing on producing persimmons, biwa, and pears. It seems that they are making new efforts by actively introducing new varieties while promoting thorough cultivation management and high-quality fruit production that meet the needs for food safety and security. Voices of executives of selecting harvest place: Making a successor: It is said that they aim to improve agricultural income by developing a vigorous and motivated production area. Specifically, in addition to improving productivity and securing production volume by coexisting with production areas, markets, and consumers and improving the production base, it is possible to secure a labor force, and promote training and training for accepting new farmers. It is a thing. In recent years, climate change has been severe and it is required to respond to it, but by providing detailed technical guidance through production-related seminars, etc., it will lead to an increase in sales power as a co-selection of Hachikyo (the entire production area). A powerful attempt. It is said that the strength of Hachikyo Co-selection is that it has various products that start from very early life starting in October and continue until around spring. In particular, “Hime mizuki and Nagomi” seem to have many requests from the market. It is believed that strengthening aspects such as increasing production of attractive products and securing stable production every year will lead to sales expansion. To create highly appealing products targeting women, children, and young people with our own hands. The members of the Hachikyo Women’s Club have gathered and the “Hachikyo Mican Club” was launched in the summer of 2015. It is said that he wanted to spread the loveliness of the official PR character “Mican” of the local Ehime, who fought for the top position at the National Yuru Chara Grand Prix in the same year, on the deliciousness of Hakkyo Mikan. At the “Product Development Conference” where everyone gathers after farming, it seems that energetic opinions are tumultuous (with everyone voicing their opinions simultaneously). It seems that ideas and ideas from the female perspective of the buying side will pop out one after another. It seems that the product that was born under such circumstances is the “petit gift” of “Hakkyo Mikan”, whose colorful design is eye-catching. Until I looked it up today, I knew it for the first time. “Hime mizuki” waits for maturity like a full moon that shines full of time, and is characterized by its dripping sweetness and fragrant acidity. It is famous as the highest quality Hakkyo brand and has many fans. It is the ultimate gem that each producer has carefully raised. As for the standard, it can be confirmed that 2 kg and 5 kg are included. The shipping time is scheduled to be from early November to mid-December. From J-PlatPat, Registration No. 4783049, Registration Date: July 2, 2004, Registration Bulletin Issue Date: August 3, 2004, Publication Date: November 13, 2003, Application Number: Commercial Application 2003 -92586, filing date: October 8, 2003, prior application right generation date: October 8, 2003, renewal application date: January 15, 2014, renewal registration date: January 21, 2014, duration Expiration date: July 2, 2024, Trademark (for search): Hime mizuki, Name (reference information): Himebituki, Himemitsuki, Himemizuki, Right holder, Name or name: Nishiuwa Agricultural Cooperative, Address or whereabouts: Yawatahama City, Ehime Prefecture, Law classification: 2001 revision of law, International classification version display: 8th edition, [Category of goods and services and designated goods or services] [Similar group code], Fruit, 32E01. The bright orange fruit is thin, with a rich sweetness and a rich, mellow texture that soothes the heart and flutters quietly. Ehime Prefecture “Ehime / Nanyo Citrus Agricultural System” (Region: Uwajima City, “Yawatahama City”, Seiyo City, Ikata Town, Ainan Town) However, on February 15, 2019, it was certified as a Japanese agricultural heritage. This is a system in which the Minister of Agriculture, Forestry and Fisheries certifies areas (agriculture, forestry and fisheries systems) that operate important and traditional agriculture, forestry and fisheries in Japan. Although it is a certified standard, the agriculture, forestry and fisheries system to be applied for contributes to the food and livelihood security of the local community. Agricultural biodiversity applies The agricultural, forestry and fisheries system is rich in biodiversity and genetic resources that are globally important for food and agriculture. Local traditional knowledge system The local traditional knowledge system provides “regional valuable and traditional knowledge and customs”, “original adaptive technology” and “agricultural, forestry and fisheries industries such as biophasic, land and water”. Maintaining a “supporting natural resource management system”. Culture, values and social organization The cultural identity and climate associated with the agricultural, forestry and fishery system to be applied for are firmly established and belong to the region. Characteristics of landscapes and seascapes, having landscapes and seascapes that have developed over the years through the interaction between humankind and the environment. Resilience to change, In Japan, where there are many natural disasters, many agriculture, forestry and fishery systems have endured natural disasters and responded to changes over the long history. Maintaining high resilience to disasters, etc. in order to preserve the agriculture, forestry and fishery system and pass it on to the next generation. Participation of various actors, participation of various actors as well as local residents in order to maintain and revitalize traditional agriculture, forestry and fisheries and related culture and ecosystem conservation systems in response to the decrease of bearers and social changes Inheriting the agriculture, forestry and fisheries system through a new system by. Promote the Sixth sector, utilize the historical value of the agriculture, forestry and fishery industry system, agriculture, forestry and fishery products, traditional culture, landscape, etc., and revitalize the region by promoting the branding of agricultural products and the promotion of tourism, etc. It is mentioned that the agriculture, forestry and fishery industry system is being preserved. Last but not least, I would like to introduce the production area. “Yawatahama City”, Ehime Prefecture”, It is located in the western part of the prefecture, at the base of the Cape Sadamisaki Peninsula, with a total area of 132.65 km2. The north faces the Seto Inland Sea, and the east is Ozu City. Adjacent to Seiyo City in the south and Ikata Town in the west. The southern half of the west side is for Kyushu across the Bungo Channel (Uwa sea). The coastline forms a rias coastline（A submergent coastline with a complex narrow bay.）. Scenic landscape. City flower: Narcissus L. (1753)（Narcissus tazetta bulb）, It grows naturally in the mountains throughout the city, and the fragrance and appearance of the flowers symbolize the city. The place name is from the Yoro era (717-724), and it is said that the origin is that Hachiman Ogami（From samurai families nationwide, such as Seiwa Genji and Kanmu Taira, the god of luck (the god of martial arts) “Yumiya Hachiman”） was erected on the beach of this place. The district was based on the delta area of the Senjo River that runs through the center, and reclamation work was already carried out during the Tensho era (1573-1592). Since then, the city has been expanded from sea to sea due to repeated landfills. Goby（Gobioidei）cultivation and shipping industry have been active in the former Honai area since the Edo period. In the Meiji era, commerce and industry such as mining, shipping, and spinning developed under the new government’s policy of promoting the breeding industry. “The development of the wholesale market for marine products and the expansion of production of mandarin oranges and other citrus fruits”. After World War II, the fishing industry developed dramatically and is famous as a base for the trawl fishery. After that, while expanding the facility as a connecting port connecting Kyushu and Shikoku, the production of citrus fruits, mainly mandarin oranges, will become the main crop of the city. In the latter half of the 1970s, the fish market facilities in Okishinden were improved and it became a popular marine product distribution base. From 1980, the Nanyo Water Supply Authority started supplying water supply, and the water shortage in summer was alleviated. On March 28, 2005, the former Yawatahama City and the former Honai Town will be added to create a new Yawatahama City. Edooka Elementary School Special Classroom Building (Non-existent) Design: Masatsune Matsumura, Completion: 1955-Around JR station. Wooden modernist architecture: Made in a rational spirit using industrial products such as iron and glass and concrete. It was a new construction method, dismissing Gothic and Baroque decorations.
【栄養素・効果効能】
Protein: macromolecule; Structural proteins make up the body, and functional proteins are proteins involved in digestion, transportation, and chemical reactions. Digestive enzymes such as pepsin（aspartic endopeptidase）and trypsin（Endopeptidase & Serine Protease）, which are cut by digestive enzymes and decomposed into small peptides and amino acids, absorbed and digested finely, are also made from amino acids.
脂質 ; It has important roles such as being used as an energy source, becoming a component of cell membranes, organs, and nerves, and assisting the transport of vitamins. It keeps a person’s body temperature, moisturizes and glitters the skin, helps normal hormones work, and has an active function. Women, in particular, can be detrimental to beauty and health and need some lipids for beautiful skin and hair. However, if the intake is too high, it will be stored as fat.
炭水化物; It is a compound of carbon（Ca）and hydrogen（H）, and is divided into sugar, which is taken into the body as food and used as an energy source, and dietary fiber, which cannot be digested by digestive enzymes in the body.
ビタミンA: C20H30O; Retinol activity equivalent (μgRAE) = retinol (μg) + 1/12 × β-carotene (μg) + 1/24 x α-carotene (μg) + 1/24 × β-cryptoxanthin (μg) + 1/24 × other provitamins A carotenoid (μg).
Lutein: C40H56O2; As an antioxidant, it is expected to have the effect of suppressing active oxygen that causes aging of the eyes, absorbing harmful light, and protecting the eyes. In addition to the eyes, the human body is found in the skin, breast tissue, breast milk, cervix, and brain.
βカロテン: C40H56; Converted to vitamin A in the body as needed.Carotenoids that are abundant in green and yellow vegetables. It is important for maintaining the health of skin and mucous membranes and for photostimulatory response, and promotes cell proliferation.
ビタミンB1; Decarbonization in the ketoglutarate dehydrogenase reaction: Coenzyme; Form of thiamine pyrophosphate.
B2; The form of flavin adenine dinucleotide as a cofactor for the α-ketoglutarate dehydrogenase complex and succinate dehydrogenase.
B6; Pyridoxine（C8H11NO3）, Pyridoxal（C8H9NO3）, Pyridoxiamine（C8H12N2O2）; Coenzyme for protein, lipid and carbohydrate metabolism: It acts as a coenzyme（Pyridoxal phosphate）for metabolism of bioactive amines, which is a neurotransmitter, and as a hormone regulator: Helps keep nerves and skin healthy, fight infections, keep blood sugar levels normal, produce red blood cells, and some enzymes work properly.
パントテン酸（Cofactor fused with active carboxylic acid residues such as Acyl coa and succinyl-coa: Coenzyme A（Cysteamine）: C21H36P3N7O16S）
ナイアシン（The form of nicotinamide adenine dinucleotide as a coenzyme of isocitrate dehydrogenase, α-ketotoglutarate dehydrogenase, malate dehydrogenase.）
ビオチン（5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid: C10H16N2O3S）: ビタミンH; It is a colorless acicular crystal that is stable to neutral, acidic, alkaline, oxygen, and light, but weak to heat. It is released from proteins in food by biotinidase（dominant gene）secreted by the pancreas. It translocates into the blood and binds to biotinidase, a transport protein synthesized in the liver.
葉酸; ビタミンM(2S)-2-[(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid: C19H19N7O6; Pteridine（C6H4N4）with para-aminobenzoic acid; PABA（C7H7NO2）and another or more glutamic acids. Most exist in the “Polyglutamic acid type” (A combination of multiple glutamic acids). I heard that it is absorbed from the epithelial cells of the small intestine after being converted to the “Monoglutamic acid type” (A form in which one glutamic acid is bound) by digestive enzymes in the digestive tract. It is soluble in acids and alkalis, but hardly soluble in pure water or ethanol, and tends to be insoluble in acetone（C3H6O）, Diethyl ether（(C2H5)2O）, Chloroform（CHCl3）, and Benzene（C6H6）. In the polyglutamic acid type folate, sugar and protein are released and released in the cooking and processing of foods and in the gastric acid environment. It is decomposed into monoglutamic acid-type folic acid by an enzyme in the small intestinal mucosa and then absorbed into the cells of the small intestine. I heard that it is converted to 5-methyltetrahydrofolic acid by the enzyme（small intestinal epithelial cell）. It is transported to the liver via the portal vein, and 50% of the whole body seems to accumulate. It is converted again and transferred to bile, which is reabsorbed from the digestive tract and supplied to tissues for transfer. It is required to return homocysteine, a risk factor for arteriosclerosis, to methionine, etc.
ビタミンC: C6H8O6; Discovered as a Skorbut preventive factor by Royal Navy doctor James Lind in 1753. It removes rust from water-soluble parts of the body, such as blood and the crystalline lens of the eye, and also restores tired vitamin E. It is absorbed mainly from the small intestine as it is without being digested by the stomach. It is then carried in the blood, stored and dispersed throughout the body. It is characterized by its “antioxidant effect”, which inhales, captures a small amount of active oxygen obtained, and detoxifies it. Excessive growth damages DNA or Protein and reduces cell function.
ビタミンE: C29H50O2; It is divided into a total of eight compounds, four tocopherols（In nature, α, β, γ, δ.）and four tocotrienols. It is absorbed into the body from the intestinal tract via the lymphatic vessels together with lipids, and has a very strong antioxidant effect. Protects unsaturated fatty acids and other fat-soluble components that make up biological membranes from oxidative damage: Included in the phospholipid bilayer of cell membranes. It suppresses the production of lipid peroxide, keeps blood vessels healthy, and suppresses the oxidation of LDL（Bad cholesterol）cholesterol in the blood. You will not have hypervitaminosis with a normal diet, as you tend not to have cumulative actions in your body.
β-cryptoxanthin: Provitamin A:C40H56O: Ester body, carotenoid. It forms mixed micelles with bile acids, fatty acids, cholesterol, etc., and is passively diffused and absorbed by small intestinal epithelial cells. Move to liver with chylomicron（Lipoprotein particles; 乳糜脂粒）. Very low density lipoprotein and “Low-Density Lipoprotein Cholesterol”: To peripheral tissues ≒ Ester body.
Violaxanthin: (1S,4S,6R)-1-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4S,6R)-4-Hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,2,6-trimethyl-7-oxabicyclo[4.1.0] heptan-4-ol; C40H56O4: The gene expression balance is clear, which makes it difficult to accumulate BCR（Caricaxanthin）and facilitates the accumulation of more metabolized VIO（Carotenoid）. It is considered as a precursor of a plant hormone called “abscisic acid（C15H20O4）” that promotes leaf fall.
ペクチン: methyl ester: J.Braconnot,1825（Rf）: Galacturonic acid: carboxyl group: -C(=O)OH
セルロース:（C6H10O5)n; The main component of plant cell sell stones and plant fibers, and the most abundant carbohydrate on earth.
ヘミセルロース（Amyloid）: Discovered by E. Schulze in 1891. The name of the polysaccharide extracted with alkali after extracting Pectin from cell wall carbohydrates. Xyloglucan（Angiospermae）: With 1,4-β-D-glucan as the main chain, the α-D-xylose residue binds to the O-6 position of the D-glucose residue of 75%. It is distributed throughout the cell wall including the middle lobe, and I hear that it is hydrogen-bonded to cellulose. Tendency to exist as a storage polysaccharide in seeds.
リグニン: Sphingomonas paucimobilis SYK-6: bacterium: Mineralization; Effective resistance to decay and feeding damage.
ビタミンP: ヘスペリジン; flavonoid: C28H34O15: polyphenol; Glycotransfer works in cooperation with vitamin C to regulate the permeability of the capillary membrane so that it does not become too permeable.
ルチン; C27H30O16: β-rutinose（(2R,3S,4S,5S)-6-[ [(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol; C12H22O10）bound to quercetin. The E-rutin group significantly increased muscle weight and lean weight in the lower limbs compared to the placebo group that ingested E-rutin-free whey protein-n = 1, isoquercitrin; C21H20O12. Research results increase potential antioxidants in the blood. It protects cells and tissues by suppressing or eliminating the generation of reactive oxygen species, and preserves the normal normality and growth of muscles, etc.
Neohesperidin; C28H34O15
シネフリン: 4-[1-hydroxy-2-(methylamino)ethyl]phenol: C9H13NO2; Used in various slimming natural health products as an alternative to the pharmaceutical ingredient ephedrine. It has effects on heart rate and blood pressure, and both pharmacological effects tend to be significantly enhanced by caffeine. From the identified risk.
オーラプテン: auraptene,7-geranyloxycoumarin: C19H22O3
テルペノイド: Aldehyde,carboxylic acid: C5: IPP, DMAPP: C10, C15, C20: prenyltransferase
ナリンギン: flavanone: C27H32O14; A glycoside in which a sugar called Neo hesperidos is bound to naringenin. When hydrolyzed with the degrading enzyme naringinase, it changes to naringenin without bitterness, so it is often used for fruit juice processing.
Apigenin; C15H10O5: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one: Suppression of mRNA splicing（Processing received after transcription-RNA polymerase ii）Transcription factor -By suppressing the expression of ets-2, the activity of microglia（小膠細胞）can be increased. Binds to the SF3B1 factor in spliceosomes.
クエン酸: C(OH)(CH2COOH)2COOH: C6H8O7; When energy is taken up by the living body, it decomposes through various processes to become a substance called acetyl-coa (active acetic acid), which binds to Oxaloacetic acid（C4H4O5）. Later, it transforms into seven types of acids and returns to citric acid. TCA cycle: A substance called “ATP (adenosine triphosphate（C10H16N5O13P3）)” that acts as an energy source for cells in the body. Effective against lactic acid, which is the source of stiff shoulders and muscle fatigue.
ブドウ糖: C6H12O6: D-グルコース; Known as a component of cellulose, starch and glycogen. D-glucose（Dextrose, an organic compound.）and pure crystalline monosaccharides produced after the starch is completely hydrolyzed. It is divided into water-containing water containing molecular water of crystallization and anhydrous water containing nothing.
酒石酸: 2,3-dihydroxy butanedioic acid:（CH（OH）COOH）2: L-(+)-Tartaric acid: It is known as a crystalline organic acid obtained by oxidizing and enzymatically decomposing maleic acid（HOOC–CH=CH–COOH: Chain unsaturated dicarboxylic acid）or fumaric acid（HOOC–CH=CH–COOH: C4H4O4: -2-ブテン二酸: Alpha hydroxy acid）.
リンゴ酸: HOOC-CH(OH)-CH2-COOH: C4H6O5; 2-hydroxybutanedioic acid; It is known as an organic acid obtained by synthesizing fumaric acid or reducing glucose. Dicarboxylic acid, in the role of an intermediate in the TCA cycle: Alpha hydroxy acid.
Kaempferol; C15H10O6
（+）カテキン: C15H14O6; Flavonoids of polyphenols. Derived from the dark brown “catechu” taken from the Acacia Mill. / Acacia (Fabaceae) trees that grow in India.There are research cases that eliminate infectivity by adhering to protruding proteins on the surface such as influenza virus.
イソロイシン（C6H13NO2:2-アミノ-3-メチルペンタン酸）; Hydrophobic amino acid（BCCA）. The role of promoting the uptake of blood glucose into skeletal muscle without an increase in blood sugar concentration. It works to suppress gluconeogenesis（A pathway that slowly reverses glycolysis from lactic acid, pyruvic acid, amino acid, propionic acid, etc. to produce D-glucose.）in the liver and to oxidatively utilize glucose. A zwitterionic compound having a leucine structural isomer and a sec-butyl group (-ch (ch3) ch2ch3) in the side chain.
ロイシン（C6H13NO2: 2-Amino-4-methylpentanoic acid）; Activator of mTOR: mammallian Target Of Rapamycin（Atypical serine-threonine kinases present in two types of complexes: It senses nutrient sources such as glucose and amino acid, and plays a role of regulators in cell proliferation, metabolism, and survival.）: There are insulin, IGF-1 (insulin-like growth factor 1: insulin-like growth factors 1), Testosterone, Nitric oxide, Muscle Contraction etc. An important factor that promotes protein synthesis（BCCA）.
リシン(リジン: C6H14N2O2: 2,6-diaminohexanoic acid); It is known as a synthetic raw material for carnitine（C7H15NO3: Derivative）required for fat burning.In the human body, we also hear examples of promotion of glucose metabolism and its relationship with calcium absorption. L-Lysine Hydrochloride: Mol fileKCF fileDB search（HCl: hydrochloric acid）.
（含硫）メチオニン（C5H11NO2S: 2-amino-4-(methylthio)butanoic acid）; It is a sulfur-containing amino acid containing sulfur and is converted into glutathione（C10H17N3O6S）and taurine（C2H7NO3S）in the body. It is also known as a biosynthetic raw material for carnitine involved in fat burning. Tendency to be metabolized in a series of reactions called carbon metabolism. Using methionine and ATP synthase as substrates, S-adenosylmethionine synthase catalyzes the biosynthesis of S-adenosylmethionine（C15H22N6O5S+）: Protein methylation.
シスチン（ C6H12N2O4S2: 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid）; The role of stabilizing the structure of Proteins. It is one of the sulfur-containing amino acids（The composition of Glutathione-SH（C10H17N3O6S）, which is important for detoxification and antioxidant activity.）containing sulfur and has a unique aroma. It converts methionine to Cystathionine（C7H14N2O4S: A catalyst for β-synthase from Homocysteine（C4H9NO2S: 2-Amino-4-sulfanylbutanoic acid）and Serine.）in the human body. It is famous as a sulfur-containing amino acid in which two molecules of cysteine are bound.
（芳香族）フェニルアラニン（ C9H11NO2: 2-Amino-3-phenylpropanoic acid）; In the brain, the role of Synthesizing Neurotransmitter Norepinephrine（C8H11NO3: 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol; Monoamine（A chemical structure in which an amino group is connected to an aromatic ring by two carbon chains.））and Dopamine（C8H11NO2: Monoamine neurotransmitter）. It is also known as a raw material for Tyrosine（C9H11NO3: 4-hydroxyphenylalanine; Protein production synthesis）. Important for accelerating the amyloid assembly process.Adrenaline（Adrenal medulla）: Epinephrine（C9H13NO3）, Produced by neurons and released as adrenal medulla hormones and neurotransmitters.
チロシン（C9H11NO3: 2-Amino-3-(4-hydroxyphenyl) propanoic acid）; Synthesized by hydroxylation of phenylalanine. When the aromatics are further hydroxylated, L-dopa（C9H11NO4: L-3,4-dihydroxyphenylalanine: (S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid.It is converted to L-Dopa by tyrosine hydroxidase and to dopamine（Nerve cells in a specific area of brain, which is the final product.）by decarboxylase. The neurotransmitter catecholamines (noradrenaline: norepinephrine（C8H11NO3）, adrenaline（C9H13NO3）: Mainly adrenal medulla（副腎髄質）cells can be metabolized, etc.) are produced from L-Dopa.）is produced. When oxidized by tyrosinase, the intermediate L-Dopa is immediately oxidized and converted to dopachrome（C9H7NO4）. It is further polymerized by the action of enzymes and converted to melanin. It is a dark brown pigment and is widely distributed in animal tissues such as skin, hair and iris. I hear that it has a role to absorb excess sunlight. A disease in which tyrosinase is congenitally deficient is known as oculocutaneous disease (albino: Mutant individuals who cannot synthesize photosynthetic pigments: 先天性白皮症) etc.
トレオニン(スレオニン: C4H9NO3: 2-Amino-3-hydroxybutanoic acid): A zwitterionic compound having an Amino group (-NH2) and a carboxyl group (-COOH) and a hydroxyethyl group in the side chain. There are two diastereomers, but only the (2S, 3R) form is called L-threonine（Since it has two optically active centers, four isomers have been identified.）. It has been suggested that it may compete with alanine, Branched Chain Amino Acids, phenylalanine, serine, tryptophan, tyrosine etc. I hear that it is the newest in history.
トリプトファン（C11H12N2O2: 2-Amino-3-(1H-indol-3-yl)propanoic acid）: A raw material for Nicotinic acid:C6H5NO2 (Niacin: Vitamin B3) in the human body and Serotonin（It is deeply related to important human functions such as mental (stress) and sleep; Endorphin）, a neurotransmitter involved in sedation and sleep-inducing action in the brain. Operate the sodium and potassium pumps to discharge the sodium incorporated into the conjugate with glutamic acid. When glutamate and lactic acid are taken up by nerve cells, the most important nerve, the glutamate nerve, begins to move. Glial cells（Oligodendrocytes（希突起膠細胞）that make myelin sheaths（髄鞘）to increase nerve conduction velocity, microglia（小膠細胞）that are responsible for central nervous system immunity, etc. Featured “astrocytes”（Glial fibrillary acidic protein Immunohistochemistry）: kallikrein-related peptidase 7:（KLK7）: Serine Protease（Proteolytic enzyme with serine group）: To elucidate the generation mechanism of neuroglioma.）take up glucose and activate glutamatergic nerves.
バリン（C5H11NO2,SMILES: CC(C)[C@@H](C(=O)O)N）: Energy is metabolized in muscle tissue and is involved in growth.Branched Chain Amino Acids（BCAA: Similar to leucine and isoleucine）: Expected to adjust the nitrogen balance in blood and improve liver function.
ヒスチジン（C6H9N3O2: 2-Amino-3-(1H-imidazol-4-yl)propanoic acid: It is said to have the effect of suppressing oxidative stress (ischaemia reperfusion), and there are cases of action such as increased insulin secretion. When neonatal screening is abnormal and when amino acid acid metabolism disorder is presumed: I heard that an increase in a specific concentration is a powerful clue to the diagnosis. In the nutritional disorder called cardiac cachexia seen in Chronic congestive heart failure, etc., aromatic amino acids increase and branched chain amino acids and histidine decrease.Since it is abundant in “hemoglobin（Proteins present in red blood cells）”, there is a risk of anemia if it is insufficient. In some cases, it was suggested that the anti-obesity effect was attenuated by “proline（Pyrrolidine-2-carboxylic acid）”.
アルギニン（C6H14N4O2: (S)-2-Amino-5-guanidinopentanoic acid）; Expected to help the body produce energy, increase growth hormone secretion, build muscle, and improve male function.Promotes fat metabolism to strengthen muscle tissue and promote height growth. TCA cycle: Adenosine Triphosphate（C10H16N5O13P3）, It enhances the function of the urea cycle in the liver and promotes the recovery of brain fatigue quickly. Ammonia（NH3）inhibits its function, but ingestion promotes detoxification. Expected to be effective as part of the Natural Moisturizing Factor（NMF）of the stratum corneum.
アラニン（C3H7NO2: 2-Aminopropanoic acid）; It is a synthetic raw material for sugar and has the energy generation function of the living body. The action of secreting the hormone Glucagon（Peptide hormone: 29 amino acid;In the Liver, it activates protein kinase a through binding to specific receptors and cyclic adenosine monophosphate (AMP: cAMP-dependent protein kinase (Protein kinase A); Protein kinase（Phosphorylating enzyme）) production., which is secreted when blood sugar concentration is low and promotes the breakdown of glycogen（C6H10O5)n: Discovered as a liver component by Mr. Claude Bernard in Burgundy, France in 1856.
アスパラギン酸（C4H7NO4: Aminosuccinic acid, asparagic acid; The role of increasing the absorption of K and Mg and decomposing and promoting lactic acid. Located closest to the TCA cycle of the body, which is the place of energy production.）It is located closest to the TCA cycle（Tricarboxylic Acid Cycle: Citric Acid Cycle）of the body, which is the place of energy production. In 1937, German’s chemist and doctor Hans Adolf Krebs finds the circuit. England: Received the Nobel Prize in Physiology or Medicine in 1953. Discovery of the Ornithine cycle of Urea synthesis: A cycle that draws out internal combustion.Decomposes fat and lactic acid and converts them into energy（Tricarboxylic Acid Cycle）.
グルタミン酸（C5H9NO4: 2-Aminopentanedioic acid: In animals, it can be synthesized from non-essential amino acids, that is, other organic compounds. Discovered by Mr. Karl Heinrich Leopold Ritthausen in 1866 in the acid hydrolyzate of gluten, a wheat protein.It is famous as a raw material for glutathione and GABA (4-aminobutanoic acid). It can be biosynthesized from “2-Oxopentanedioic acid” and “ammonia（NH3）”. It conveys information to nerves by binding to and activating N-methyl-D-aspartic acid (NMDA) -type receptors. D-serine（It has the enzyme serine racemase (SRR) synthesized by Glial cells（It acts to give an energy source to nerve cells in the brain and builds an energy environment: A cell that fills parts of the brain other than nerve cells and supports the functions of nerve cells from various aspects.）located in a specific region of the hippocampus.）regulates stimulus volume. It is believed that the Synapse connection will be strengthened, giving memory and learning. There seems to be a hypothesis that the diseases alzheimer dementia and amyotrophic lateral sclerosis are caused by too much stimulation of the “NMDA receptor”.）
グリシン（Glycocholic: C2H5NO2: Aminoethanoic acid）; In the Nerve system, it also functions as an amino acid (Collagen: Protein, Elastin（Elastic fiber）, Keratin（△Cystine）, Sericin（C30H40N10O16）.), which is mainly responsible for inhibitory synaptic transmission between the brain stem and spinal cord. The feature is that there are no stereoisomers（The opposite sex with different three-dimensional directions of atoms in space.）such as D-form and L-form. Not only does it improve the shelf life of food, but it also has a sweet taste and is used as a seasoning. Porphyrins（Porphyra; Hemoglobin as an oxygen carrier in human blood (Erythrocyte) is prominent.） related to the function of carrying oxygen in the blood and creatine（C4H9N3O2; A small amount in the brain.）essential for muscle exercise.
プロリン（C5H9NO2,SMILES: OC(=O)C1CCCN1）: The main composition of collagen（Protein; A polymer compound formed by linking (polymerizing) a large number of 21 types of amino acids in a chain: Hydroxyproline（C5H9NO3））, which is abundant in gelatin and animal skins.When stored, aspartic acid tends to decrease and increase. It is high in fruit amino acids.
セリン（C3H7NO3: 2-Amino-3-hydroxypropionic acid）; A raw material for Phosphatidylserine（C13H24NO10P,Phospholipid- Signal transduction）, a component of cell membranes. It is one of the important moisturizing ingredients to maintain the moisture content of the skin, and can be a raw material for “glycine” that is close to the same ingredient. It is the Natural Moisturizing Factor (NMF: Small molecules such as Amino acids, pyrrolidone carboxylic acids (and their salts), urea, mineral salts, organic acids (and their salts).) of the skin and is the most abundant in amino acid.
エリオシトリン: C27H32O15
ネオエリオシトリン: Eriodictyol（C15H12O6）; It is metabolized and absorbed by eriodictyol and found in blood and urine as a glucuronide conjugate.Similarly（homoeriodictyol（C16H14O6）, hesperetin（C16H14O6））, the role of inhibitory activity of lipoxygenase (5-LOX and 12-LOX).
ノミリン: TGR5; Transmembrane G protein-coupled Receptor 5: G protein-coupled receptor: C28H34O9 (mw514.57). Bile acids exert anti-obesity and anti-hyperglycemic effects through a G protein- coupled receptor TGR5: Ligand active food ingredient.By binding, it promotes insulin secretion from L-sell. It promotes the secretion of hormone GLP-1. In the living body, it binds to TGR5（G protein-coupled bile acid receptor）of skeletal muscle to increase heat production and exerts an anti-obesity effect through increased energy consumption. The non-sugar moiety that remains after the glycosyl group of the glycoside is replaced by a hydrogen atom: Aglycone; Phytochemical.
リモネン: monoterpene: 1-Methyl-4-(1-methylethenyl)-cyclohexene: C10H16; A terpenoid compound having two double bonds in which two isoprene units (C5 units) are linearly bonded to form a single ring (six-membered ring).
Acridinone, 1948: C13H9NO
ポリメトキシフラボノイド類（PMF）:ノビレチン（C21H22O8）; Long-term potentiation in the hippocampus (LTP): In cognitive impairment such as Alzheimer’s disease, synaptic plasticity disorder occurs due to various factors. cAMP response element-binding protein（cAMP-responsive element）, I hear that it is cre-dependent transcriptional activity that follows. Expected to have Aβ deposition inhibitory effect and nerve growth factor (NGF) -like effect.
タンゲレチン（C20H20O7）
シネンセチン（C20H20O7）; InChI=1S/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(27-14)10-17(24-3)19(25-4)20(18)26-5/h6-10H,1-5H3,SMILES: COc1ccc(cc1OC)c1cc(=O)c2c(OC)c(OC)c(OC)cc2o1,及び,3,5,6,7,8,3′,4′-ヘプタメトキシフラボン（HMF）: Induces the production of brain-derived neurotrophic factor (BDNF; 脳由来神経栄養因子).
γ(gamma)-aminobutyric acid: C4H9NO2; It is responsible for inhibitory synaptic transmission of the rostral central nervous system（Free amino acid series）. Glutamic acid by decarboxylation catalyzed by glutamic acid decarboxylase (enzyme: GAD67(GAD1: cytoplasm), GAD65(GAD2: presynaptic terminal)). TCA cycle α-ketoglutaric acid（C5H6O5）to glutamic acid. In some cases, blood pressure lowering effect is achieved by suppressing the release of norepinephrine from pars sympathica: Ion channel type receptor etc.
ポンシリン: (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4, 5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one; C28H34O14: Flavonoid glycoside with the structure of isosakuranetin（C16H14O5）7-O-neoheseridoside. It acts to inhibit osteoclast differentiation and bone loss through down-regulation of NFATc1（Nuclear factor of activated T-cells, cytoplasmic 1: OSCAR,TREM-2,PIR-A etc.）in vitro and in vivo.
ネオポンシリン（ジジミン）: (S)-7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; C28H34O14: Suppression of NF-κB（Protein complex; Nuclear factor-kappa B）activation: Prevent vegf Induced angiogenesis in vitro and in vivo.
カリウム: K; It interacts with “Sodium”, which is abundant in extracellular fluid. It works to maintain the osmotic pressure of cells and retain water. After ingestion and absorption in the small intestine, it is transported to tissues throughout the body, most of which is excreted by the kidneys. It is maintained by regulation of reabsorption in the kidney, and the k concentration in blood is maintained between 3.6 and 4.8 meq / l. Together with sodium, it maintains cell osmotic pressure. It works to suppress nerve stimulus transmission, functional regulation of heart and muscle, and intracellular enzyme reaction（I have to add proton transfer equilibrium）. I heard that about 200g is contained in the body of an adult, Potassium.
カルシウム: Ca; In the body, the amount in cells and blood is strictly controlled. Tendency to move from bone to blood as needed. About 99% is stored in bone, but also in the blood of cells and muscles. If you don’t get the calcium you need, you risk mobilizing large amounts of calcium in your bones and weakening your bones. To maintain normal blood calcium levels, it is necessary to take at least 1000-1500 mg daily. Parathyroid hormone（PTH）and Thyrocalcitonin（Made by the cells of the thyroid gland, hormones have the function of lowering the calcium concentration in the blood by delaying the breakdown of bones.）; It is made up of four parathyroid glands behind the thyroid gland in the neck.As the calcium concentration in In blood rises, the amount of hormones produced by the parathyroid glands tends to decrease. It stimulates bones to release calcium into the blood and reduces the amount of calcium excreted by the kidneys into the urine. Increases calcium absorption by stimulating alimentary canal to increase calcium absorption by promoting the activation of vitamin D in the kidneys.
マグネシウム: Mg; Vinegar has been known to solubilize insoluble calcium (Ca) and magnesium (Mg) in food, however, the difference in solubilization ability among various kinds of vinegar has not been investigated. In this study, solubilization of Ca and Mg from coral powder and beef bone powder was compared with several kinds of vinegar. Calcium solubilization was observed to be high in grain vinegar, cider vinegar and wine vinegar, and low in rice vinegar and un-polished rice vinegar. On the other hand, magnesium solubilization was high in rice vinegar, wine vinegar and cider vinegar, and low in grain vinegar and un-polished rice vinegar. Calcium solubilization of coral powder was significantly negatively correlated with the pH of vinegar, while Mg solubilization was not. Comparison of solubilization of Ca in un-polished rice vinegar and acetic acid solution suggested that the phosphorus content was also responsible for solubilization in un-polished vinegar. These results suggest that ingredients in vinegar, as well as acidity and pH, affect solubilization of Ca and Mg from food when cooked with vinegar. Characterization of Solubilization of Insoluble Calcium and Magnesium with Various Kinds of Vinegar,Nakano Central Research Institute, Nakano Vinegar Co., Ltd. and Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University with Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology 45(11), 655-662, 1998-11-15）
ナトリウム: Na; In the adult body, most of it is contained in extracellular fluid outside the cell. Approximately 50 % as salt (sodium chloride), bicarbonate, phosphate. About 40 % is present in the build and is slightly contained in the intracellular fluid. Functions such as osmotic pressure adjustment: Roles such as maintaining the amount of extracellular fluid. Normally, healthy people do not have a deficiency. It is possible to promote the excretion of sodium by taking vegetables and fruits that are high in potassium together. This is because it has been confirmed that taking too much increases the risk of swelling, thirst, high blood pressure, stomach cancer, and esophageal cancer.
リン: P;（Leakage in urine causes symptoms such as hypoproteinemia, decreased renal function, and hyperphosphatemia.）The amount of phosphorus per 1 g of protein contains about 15 mg, and the intake correlates with the protein intake. The role of combining and strengthening bones and teeth. Higher blood phosphate levels tend to make bones brittle. Calcium tends to combine and become coal in other than bones such as blood vessels and tendons.
鉄: Fe; It is attracting attention as one of the world’s three major deficient micronutrients along with vitamin A and Iodine（I2; In 1811, Discovered by burning seaweed with potassium carbonate, which is the raw material for potassium nitrate by Bernard Courtois（仏）.）Non‐heme iron（Fe）（Included in vegetables, eggs and milk.）; By taking it with foods rich in high-quality protein and vitamin C, the absorption rate into the body is improved. Fe shortage of women due to blood loss, a big problem for expectant mother and lactating women whose demand increases. Due to the metabolism of the body, about 1 mg of iron（Fe）is lost in adult men and about 0.8 mg in women per day. Ferritin（A globular protein complex consisting of 24 proteins.）has a role of suppressing deficiency and excess, and is also called stored Fe. About 90% of anemia is iron deficiency, which is deficient in fe, one of the important materials of hemoglobin.
銅: Cu; It has been known for a long time as a trace essential mineral, which is present in the human body at about 80 mg. It binds to proteins and plays a role in catalyzing a wide range of in vivo reactions. Tendency to be mainly present in bone, skeletal muscle and blood. Although it is involved in hematopoietic function as well as Fe, no reports have been heard regarding the adverse effects of chronic overdose, except for some diseases. Monovalent compounds exist as insoluble salts and complex salts. Divalent salts and complex salts are common. It is absorbed from the small and duodenum and transported to the liver through the portal vein. I hear that the lower the intake, the higher the absorption rate, and the higher the intake, the lower the absorption rate.Large amounts of divalent iron and tin ions competitively inhibit the absorption of copper from the gastrointestinal tract. Inborn errors of copper metabolism（Wilson’s disease）: Protein binding: Hepatolenticular degeneration.It acts as a Cu enzyme and acts as a catalyst for various reactions such as O2 transport, electron transfer, redox, and O2 addition. Important for Fe metabolism and transport, removal of active oxygen, and metabolism of neurotransmitters. Deficiencies can result from hereditary malabsorption or are acquired, but are not found in the normal life of healthy people. On the other hand, cases of symptoms are given to Babies whose main source of nutrition is low-content milk.Insufficiency may cause anemia, leukopenia, and bone abnormalities that do not respond to Fe administration. In addition, there are decreased immune function, cardiovascular abnormalities, and abnormal cholesterol and glucose metabolism. However, this is less frequent.
亜鉛: Zn; Zinc‐deficiency symptom: A state in which the zinc concentration in the blood is below 80 μg / dL to 130 μg / dL. Dermatitis, stomatitis, alopecia, pressure ulcer due to lack. Loss of appetite, developmental disorders, hypogonadism, susceptibility, dysgeusia, anemia, infertility, etc.Various symptoms occur and tend to improve with zinc supplementation.
マンガン: Mn; Functions as an enzyme activation and a component of metal enzymes.It is a silver-white metal with an atomic number of 25 and an atomic weight of 54.94, and its surface is oxidized in the air. I hear that 12（For a weight of 70 kg）to 20 milligramme is present in the body of an adult. It acts directly with many elements, gradually reacts with water, and is easily dissolved in acids. Absorbed by inhalation, oral or transdermal: Ingested from the diet, it dissolves as divalent by gastric acid and becomes trivalent by the oxidative mechanism of intestinal cells. It is absorbed, transported to the liver through vena portalis, secreted from the bile into the intestinal tract, and mostly excreted as feces. Since absorption competes with Fe, manganese tends to be less likely to be absorbed if the iron content in the diet is high. It is abundant in mitochondria, and is contained in high concentrations in pigmented areas in the body such as the retina, hair, and skin pigmented areas. It suggests specific and non-specific effects on many enzyme activities such as oxidoreductase, hydrolase, dehydrogenase, and transferase. It is also a component of arginine-degrading enzyme, lactate dehydrogenase, and manganese superoxide dismutase (MnSOD). Examples include connective tissue and bone formation, inner ear growth formation, glucose tolerance, fertility, lipid metabolism, growth and involvement in brain function.
【効果・効能】
抗癌作用: Anti-cancer effect
抗酸化作用: Antioxidant effect
抗菌作用: Antibacterial effect
抗腫瘍性: Anticancerous
肩こり: Stiff shoulder
腰痛: Lumbago
髪の毛健康: Hair health
風邪予防: Prevention of cold
美肌・美容: Beautiful skin and beauty
老化防止: Prevention from getting older
ダイエット: Diet
むくみ解消: Edema
利尿効果: Diuretic effect
女性ホルモン: Female hormones
妊婦: Expectant mother
貧血: Anemia
疲労回復: Recovery from fatigue
視力維持: Maintaining eyesight
消化促進: Digestion promotion
殺菌効果: Bactericidal effect
骨粗しょう症: Osteoporosis
新陳代謝: Metabolism
ストレス解消: Stress relief
活性酸素抑制: Reactive oxygen species suppression
喉・呼吸器安定: Throat, respiratory stability
皮膚粘膜強化: Skin and mucous membrane strengthening
高血圧: Elevated blood pressure
肥満: Corpulence
生活習慣病: Life style related disease
血中コレステロール緩和: Blood cholesterol relief
コレステロール: Triglycerides
二日酔い: Overnight drunkenness
心筋梗塞: Heart infarction
脳梗塞: Brain infarction
血栓予防: Thromboprophylaxis
食欲不振: Anorexia
精神安定: Tranquilize
認知機能改善: Cognitive function improvement
胃潰瘍: Gastric ulcer
胃腸障害: Gastrointestinal injury
Wenshu mandarin, a specialty product of Hachikyo, has carefully selected sugar acid balance standards with a taste sensor. A superb product with a very thin sac membrane and a mellow texture. Under safe production and production control with an emphasis on taste, we select oranges that have a good balance of sweetness and acidity with an optical sensor from carefully cultivated oranges, and those that pass the standards are shipped. The bright orange fruit has a rich sweetness and a rich smile that makes you smile.
The Hakkyo brand keeps a production diary for all producers and the instructor checks the contents to manage cultivation and deliver safe and secure citrus fruits to consumers. We have also obtained certification approval from an external inspector for our efforts on the Zen Nooh Safety System. In addition to Citrus unshiu and middle late-ripening citrus (e.g. pomelo), we also cultivate local specialties such as loquat, pear, and Fuji persimmon. It seems that they are actively introducing new varieties to revitalize the region.
Waiting for maturity like a full moon that shines full of time, it is characterized by dripping sweetness and fragrant acidity, and Hakkyo’s finest selection of fruits with a good balance of sugar content and acid from among the fruits that have worked on high quality production brand. It is the ultimate gem that each producer has carefully raised.